These are the most common side effects of nystatin. More severe side effects may be possible, but you should discuss them with your doctor before taking nystatin to make sure that they won’t interfere with your treatment. If you do experience any side effects while taking this medicine, stop using it and tell your doctor or pharmacist as soon as possible.
Treatment for skin infections (miliary dermatitis) can sometimes help reduce sweating problems associated with nystatin therapy. Ask your doctor if using corticosteroids (such as prednisolone, prednisone), azathioprine or cyclophosphamide may be helpful in treating this condition if it does not improve on its own after several weeks of antibiotic treatment for an underlying infection.
Nystatin is a topically applied agent that works by killing bacteria in the upper layers of the epidermis. Nystatin has no effect on bacterial activity deeper than 4 microns, so it will not kill germs inside blood vessels or other infections deeper than 4-8 microns below the surface.
topical antifungal agents work mainly by disrupting fungal cell membranes; however, some topical antifungals act by interfering with metabolic enzymes required for growth and division. The more serious adverse reactions include allergic reactions such as rashes and itching; migraines; changes in color vision