The Special Sensory Neuron (SEN) in the brainstem controls sweating and cuts off sweating when it is not needed. The neural pathway from the SEN to sweat gland neurons has been identified with microelectrode recordings. This pathway activates both sympathetic and parasympathetic pathways at different rates, depending on whether a person is “hot” or “cold”. In humans, this may explain why some people perspire more than others.
Why do some people have unusually high levels of body temperature? [ edit ]
In some genetic syndromes that cause hyperhidrosis, there are genes involved in sensing temperature changes. These disorders can be due to a mutation of a gene found only in one family line – for example, SLC26A2 which codes for an ion channel protein called Sweat-Associated Locomotor Innervation Factor 2 (SALIF-2) – leading to increased temperatures, or because of mutations within other genes such as CACNA1C encoding for calcium channels. Heterozygotes can show higher oral temperatures compared with homozygous cases. There are also many variants of these genes which may affect heat production linked to axons. Some people even have very mild forms of hyperhidrosis but still notice a significant amount of sweating especially under their arms via shirt armpits while others believe they don’t sweat at all even though they do if you look