Excessive sweating can manifest from a multitude of causes, different in every case. In the vast majority of cases it is due to overactivity or hyperactivity of the hypothalamus-pituitary axis (HPA). HPA control over sweating occurs at several levels: by feedback mechanisms that inhibit excessive secretion of antiperspirants and their derivatives; by direct input from sweat glands themselves; and through sympathoadrenal reflexes that reduce sympathetic nervous system activity. The latter two systems are responsible for most abnormal sweating conditions, such as primary central autonomic failure .
A number of factors influence HPA activity  including:
• Hypothalamic injury (e.g., pituitary adenoma) or trauma (e.g., surgical removal) to the pituitary gland itself results in an increase in CRF concentrations in circulation and a decrease in plasma ACTH concentrations , which results in decreased limb vasodilation and reduced epinephrine release upon stimulation with ADX-31 . This relative deficiency in ADX-31 production results only transiently because acute increases occur spontaneously following destruction or dysfunction of other HPA components such as corticotrophin releasing factor (CRF), adrenocorticotropic hormone (ACTH), melanocyte stimulating hormone(MSH), prokineticin II, neuropeptide Y, somatostatin, etc.; however sustained increases may result if no compensatory mechanism