What Can Cause Excessive Underarm Sweating?

Excessive sweating is a common problem, but it is usually caused by excessive levels of the hormone pde5. Pde5 is produced in the adrenal glands and causes increased sweat production when activated. This can be done with drugs such as antidepressants, beta-blockers and some chemotherapy drugs.

In addition to this there are other conditions which cause hyperhidrosis on their own:

1) Adrenal gland disorders: The most common type of adrenal gland disorder that has been associated with excessive underarm perspiration is Addison’s disease – an auto-immune condition where the body targets its own adrenals for destruction – resulting in low cortisol levels and a deficiency in corticosteroid production. It also results in fat redistribution (usually around abdomen) due to impaired glucose regulation (which leads to weight gain, high blood sugar). Excess salt intake may result from loss of sodium chloride absorption or extra excretion because of hypo-functioning kidneys; diabetes mellitus; obesity; age; stress; poor nutritional status (malnutrition); alcoholism/drug abuse and pregnancy can all lead to excess sodium retention leading to higher than normal serum osmolality, causing water retention that concentrates into adipose tissue leading to weight gain or central obesity [2]. If left untreated Addison’s disease may progress into chronic renal failure [3] . Another example would be Cushing syndrome associated with pituitary adenoma tumors which causes both hypercortisolism

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